I built my system and am running Vista 64.I have had few if any problems. Your problem is that factory built systems ie...HP, Dell and etc..have installed their own software that is not totally compatable. Also, some 32 bit and few if any 16 bit software will run on a 64 bit system. It is up to software MGF to write software that will run on an OP not the other way around. It would be impossible for Mircosoft or any other Compoany to write an OP for every program. As I suggest to everyone having these problems, backup your data then reformat and reload all compatable software except MFG software. I believe this will solve most of your problems.